The structural heterogeneity of chorial villi phenotype determined by angiogenesis. Implications in legal pathology

Abstract

Micro anatomic phenotype of chorial villi can be achieved only by means of a rigurous evaluation of its structural elements: trophoblast, vascular and mesenchyme. The authors proposed themselves to study the reciprocal relations between syncytiotrophoblast, fetal sinusoid capillaries and argentic collagen fiber fascicles inside chorial villi depending on angionesis process. The research was carried out on human biologic material using placenta fragments during 28-37 weeks of gestation. The authors consider that the collagen IV stereo distribution inside the vascular pedicle of the terminal villi, contributes to the stability, biodynamic and biokinematics of villi phenotype that is determined by branching or non branching angiogenesis. The personal results have a great value for stating the variability limits of terminal villi phenotype in ortology as well as in general or forensic pathology. Key W ords: terminal villi, angiogenesis, collagen IV, villi phenotype