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Abstract
The adenine nucleotide ATP relaxed the tracheal strip of the guinea pig, while the methylene isosteres of ATP, α,β-methylene ATP (APCPP) and β,γ-methylene ATP (APPCP) in concentrations up to 100 μM were either inactive or produced a small contraction. The relaxation of the tracheal strip elicited by ATP was completely abolished by treatment of the tissue with indomethacin, a prostaglandin synthesis inhibitor. The relaxations induced by ATP in the guinea-pig taenia coli were followed by a rebound contraction which could be blocked by indomethacin. The two methylene analogues of ATP, produced relaxations in the taenia coli which were not followed by a rebound contraction. It is concluded that in the guinea-pig tracheal chain and taenia coli preparations ATP stimulated prostaglandin synthesis while the analogues modified in the polyphosphate chain were unable to do so.
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