Abstract
The platelet-derived growth factor receptors (PDGFRs), including the PDGFRα and PDGFRβ, are typical class III receptor tyrosine kinases. They regulate important physiopathylogical processes, including angiogenesis, wound healing, and tumor cell proliferation, migration and survival. Overexpression of platelet-derived growth factors (PDGFs) and their receptors or activating mutations of PDGF receptors had been linked to a series of diseases, such as tumorigenesis, fibrosis and cardiovascular diseases. Therefore, PDGFs/PDGFRs had been validated as important therapeutic targets in the treatment of these diseases. Herein, we reviewed the progress in the structural and functional studies of PDGFR signaling, their regulation, and their association with human diseases. In addition, we discussed the therapeutic strategies undertaken on targeting dysregulated PDGF/PDGFR signaling. Moreover, we provided our perspectives on future research directions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
