Abstract
The stochastic model of molecular evolution was used to makea priori predictions for the total number of one-step nucleotide changes required to account for a given observed number of nucleotide substitutions between two homologous nucleic acids. The experimental deviations from randomness found for eukaryotic transfer RNAs and summarized by Dayhoff and McLaughlin (1972) are shown to affect only slightly the quantitative predictions of the model. This is true for both short and long periods of evolutionary divergence. The model can thus be used with some confidence for quantitatively correcting the branch lengths of phylogenetic trees derived from either nucleic acid sequence or hybridization data.
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