Abstract
This chapter focuses on the Orai proteins, Orai1-3 in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It starts by reviewing briefly the defining characteristics of the CRAC channel, then discusses the first studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines some insights from cell biological and electrophysiological studies of recombinant Orai proteins.
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