The Steroid-Induced Peptic Ulcer

Abstract

Introduction The advent of corticotropin (ACTH) and the development of symptoms in patients on steroid therapy have led to a reevaluation of the peptic problem. Peptic previously occurred largely in a certain type of person who was said to have an ulcer diathesis, but the introduction of new ulcerogenic agents has somewhat changed the picture. It is to be noted that most of these ulcerogenic agents are antiarthritic or antirheumatic compounds, and our material is obtained from patients suffering originally from these chronic ailments. The frequency of peptic ulceration in patients on steroid therapy appears to be more than coincidental. Although a medical program and discontinuance of the offending agents usually suffice, there are times when complications of the arise which demand surgical intervention. Our experience with this type of and its complications forms the basis of this report. Physiological Considerations Peptic has