Abstract
Reactions of both axial and equatorial cholestan-3α- and -3β-yl mesylates and tosylates with sodium diarylphosphides give cholestanylphosphines in good yield and with complete inversion of stereochemistry. The stereochemistry has been established by an X-ray crystal structure of (5α-cholestan-3α-yl) diphenylphosphine oxide, and a general method for distinguishing between axial and equatorial phosphines based on 31P N.M.R . spectra is presented. The monophosphines were used as ligands in asymmetric hydrogenation, but only low optical yields were obtained.
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