Abstract
BackgroundIt has been proved that hepatitis B virus (HBV) infection alters the metastatic pattern and affects survival in colorectal cancer (CRC) and hepatocellular carcinoma (HCC), while the influence of HBV infection on metastatic pattern and survival in patients with pancreatic cancer (PC) has not been investigated yet.MethodsWe conducted an investigation to evaluate the impact of HBV infection on metastatic pattern and overall survival in PC. We collected the data of 460 PC patients treated in our hospital from 1999 to 2010. Serum HBV markers were tested with enzyme-linked immunosorbent assay. The impact of HBV infection on metastatic pattern and overall survival was analyzed.ResultsWe found that the incidence of synchronous liver metastasis was significantly higher in patients with HBsAg positive than those with HBsAg negative (46.0% vs 32.0%, P < 0.05), and higher in chronic HBV infection (CHB) group than both non HBV infection and resolved HBV infection group (61.1% vs 33.9%, P < 0.05, and 61.1% vs 28.7%, P < 0.05, respectively). What’s more, Kaplan-Meier analysis showed that CHB, resolved HBV infection and non HBV infection group had significant longer overall survival (OS) compared with inactive HBsAg carriers (IC) group (P=0.037, P=0.009, and P=0.019 respectively). But, in the multivariate analysis, only the CHB and non HBV infection group had significant better overall survival compared with IC group (P=0.010 and P=0.018 respectively).ConclusionsOur study found that HBV infection increased synchronous liver metastasis rate, and HBV infection status was an independent prognostic factor in PC patients.
Highlights
It has been proved that hepatitis B virus (HBV) infection alters the metastatic pattern and affects survival in colorectal cancer (CRC) and hepatocellular carcinoma (HCC), while the influence of HBV infection on metastatic pattern and survival in patients with pancreatic cancer (PC) has not been investigated yet
Study population Based on the discharge diagnosis, Data of Patients treated at Sun Yat-sen University Cancer Center in Guangzhou, China from February 28, 1999 to March 31, 2011 who were diagnosed with pancreatic adenocarcinoma were retrospectively collected. 460 histopathologically confirmed cases with available test results for HBV infection were enrolled in the final analysis. 442 cases were excluded from the study since they were diagnosed with other types of pancreatic cancer, had no record of pathologic or imaging results
63 (13.7%) patients were enrolled in hepatitis B surface antigen (HBsAg) positive group (CHB +inactive HBsAg carriers (IC)), and 397 (86.3%) patients were classified into HBsAg negative group
Summary
It has been proved that hepatitis B virus (HBV) infection alters the metastatic pattern and affects survival in colorectal cancer (CRC) and hepatocellular carcinoma (HCC), while the influence of HBV infection on metastatic pattern and survival in patients with pancreatic cancer (PC) has not been investigated yet. Pancreatic cancer (PC) is one of the most aggressive diseases among digestive system malignancies. With both high incidence and mortality rate, it is responsible for the fourth leading cause of cancer in the USA [1]. Though less common in developing countries, the mortality rate of PC has been keeping increasing in the past decades and reached the sixth place among all malignancies in China [2]. Palliative treatments, mainly chemotherapy, radiotherapy, interventional therapy and immunotherapy, contribute limited survival benefit
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