Abstract
Radiation therapy has long played a vital role in the overall management of malignant brain tumors. Conventional photon irradiation, delivered with standard fractionation (1.8 Gy - 2 Gy/F, one fractionation per day, five days per week) to total doses of 60-66 Gy, has proven to be effective in the long-term control of low-grade gliomas and to provide prolongation of local control and median survival in high-grade tumors. However, local control and survival of patients with high-grade gliomas (Grade III-IV astrocytomas, glioblastoma multiforme) remains dismal and has not improved significantly for a number of years.
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