Abstract
Genital mycoplasmosis in cows is a disease accompanied by a latent course, which complicates its timely diagnosis and the appointment of specific treatment. This disease may lead to infertility. An obstacle to the introduction of pathogens into the epithelium of the mucous membrane is a variety of defense mechanisms. A study of the state of the protective properties of the vaginal mucosa in healthy and mycoplasma-infected cows was carried out by determining the concentration of hydrogen ions and immunoglobulins in vaginal secretions. The results of the study showed a shift in the reaction of vaginal secretions towards neutrality in mycoplasmosis. Thus, the persistence of mycoplasmas in the mucous membrane of the vagina of cows causes a change in the protective properties of the vaginal secretion, as a result of which conditions are created that promote the activation of pathogenic microflora.
Highlights
The attention of veterinary specialists has been drawn to diseases that are not accompanied by specific clinical manifestations and are characterized by a long course
Based on the foregoing, it was of interest to us to compare the state of protection factors of the vaginal mucosa in healthy cows and cows with genital mycoplasmosis
The content of immunoglobulins of the classes Ig G, Ig M, Ig A and secretory immunoglobulin A (sIg A) was determined by the method of radial immunodiffusion in a gel according to Mancini
Summary
The attention of veterinary specialists has been drawn to diseases that are not accompanied by specific clinical manifestations and are characterized by a long course. Irreversible functional and morphological changes develop in the body, leading to the premature exclusion of animals from economic use One of these diseases is mycoplasmosis, and in particular its genital form [1, 2]. One of the most important specific protective factors is the immunoglobulin composition of vaginal secretions, especially the content of secretory immunoglobulin A (sIg A) in it. This class of immunoglobulins prevents the adhesion of infectious agents to the epithelial cells of the histohematogenous barrier due to the formation of immune complexes, and neutralizes the biological activity of pathogens. Based on the foregoing, it was of interest to us to compare the state of protection factors of the vaginal mucosa in healthy cows and cows with genital mycoplasmosis
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