Abstract
Murine embryonal carcinoma (EC) cells do not express virus-specific T antigen following infection with SV 40. To investigate this block in T antigen expression, the state of the viral DNA in SV 40-infected EC cells was examined. When assayed by filter hybridization and transfection, SV 40 DNA was present in 247DESC12 EC cells at early times after infection, but was lost with continued growth of the infected EC cell cultures. Although PCC4azal EC cells were T antigen negative following infection with SV 40, T antigen was expressed in a small percentage of differentiated cells when infected with SV 40 following DMA treatment. In addition, T Ag was not expressed in PCC4azal EC cells infected with SV 40 and subsequently differentiated with DMA.
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