THE STATE OF PRO-INFLAMMATORY MARKERS IN PATIENTS WITH METABOLIC DISORDERS CAUSED BY OBESITY BEFORE AND AFTER BARIATRIC SURGERY

Abstract

Aim. To study the effect of bariatric surgery on pro-inflammatory markers and to study the mechanisms of changes in their concentration in the postoperative period with a decrease in the mass of adipose tissue.
 Material and methods. The work is based on the results of surgical treatment of patients with MO (aged 18 to 62 years, with an average BMI of (50.8 +8.5) kg/m2) who underwent bariatric surgery at the National Institute of Surgery and Transplantology of the National Academy of Medical Sciences of Ukraine. In the postoperative period, the following parameters were measured: C-reactive protein, sialic acid and seromucoid at 1, 3, 6 and 12 months after surgery.
 Results and discussion. The SRP concentration decreased significantly already during the first 3 months. in all groups: SRP after BSH was — (96±12.6) mg/l, which is 2 times lower than the initial level, after IR — (98±21.6) mg/l, which is 1.2 times lower than the initial level, after BPS — (128±18.6) mg/l, which was 1.3 times lower than the initial level. After 12 months. SRP was (62±10.8) mg/l, which was 3 times lower than the initial level, after IR — (46±8.4) mg/l, 3 times lower than the initial level, after BPH — (36±13.2) mg/l, which was 5 times lower than the initial level.
 Sialic acid levels at 6 months. was: after BPSh — (2.4±0.9) Od., after IR — (2.7±0.3) Od after BPSH — (2.6±0.5) Units. After 12 months. the level of sialic acids remained in the upper limit of the norm and were: after BSh — (2.7±0.5) Odes after IR — (2.5±0.7) Odes after BSA — (2.6±0.5) Units.
 The seromucoid concentration was the highest before surgery in the CI and BPS groups and amounted to (0.4±0.2) and (0.3±0.2) Compared with (0.2±0.2) in the BPS group. Within 3–6 months. after the operation, the concentration of seromucoid was in the upper limit of the norm.
 Conclusions. The reduction in body weight achieved after bariatric surgery leads to the normalization of pro-inflammatory status, which forms the pathogenetic basis for neutralizing the systemic inflammation observed in obesity. These indicators are reliable evidence of a decrease in the intensity or cessation of inflammatory and destructive processes that develop in obese patients.