The State of Machine Learning in Spine Surgery: A Systematic Review.

Abstract

This was a systematic review of existing literature. The objective of this study was to evaluate the current state-of-the-art trends and utilization of machine learning in the field of spine surgery. The past decade has seen a rise in the clinical use of machine learning in many fields including diagnostic radiology and oncology. While studies have been performed that specifically pertain to spinal surgery, there have been relatively few aggregate reviews of the existing scientific literature as applied to clinical spine surgery. This study utilized Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to review the scientific literature from 2009 to 2019 with syntax specific for machine learning and spine surgery applications. Specific data was extracted from the available literature including algorithm application, algorithms tested, database type and size, algorithm training method, and outcome of interest. A total of 44 studies met inclusion criteria, of which the majority were level III evidence. Studies were grouped into 4 general types: diagnostic tools, clinical outcome prediction, surgical assessment tools, and decision support tools. Across studies, a wide swath of algorithms were used, which were trained across multiple disparate databases. There were no studies identified that assessed the ethical implementation or patient perceptions of machine learning in clinical care. The results reveal the broad range of clinical applications and methods used to create machine learning algorithms for use in the field of spine surgery. Notable disparities exist in algorithm choice, database characteristics, and training methods. Ongoing research is needed to make machine learning operational on a large scale.