Abstract
Treatments for locomotive organs, such as bone and joint, have been investigated and preceded in recent decades. Especially, in orthopaedic field, therapeutic alternatives for total joint arthroplasty for osteoarthritis and spinal fusion have remarkably advanced. However, bone regeneration required in massive bone defect or broad spinal fusion have been treated with bone graft mainly using auto grafted bone here in Japan. These methods have several issues such as limited bone regeneration or pain in harvest sites. We would like to describe perspectives and biology in bone regeneration focusing on bone morphogenetic protein (BMP).
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