Abstract
BackgroundEpidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effectively block this connection. In this study, we further explored the underlying mechanism by constructing an AD mouse model.MethodsFemale BALB/c mice were randomly divided into four groups (n = 10/group). The AD mouse model was established by 2,4-dinitrochlorobenzene induction with repeated ovalbumin challenge. AS1517499 and corn oil were used as treatment interventions. The features of airway inflammation, remodeling, and hyperactivity were analyzed.ResultsActive use of AS1517499 in AD mice effectively reduced Th2-related cytokine levels, alleviated airway eosinophil and lymphocyte infiltration, and regulated GATA3/Foxp3 levels and subepithelial collagen deposition. These changes might be due to specific blockade of the STAT6 signaling pathway.ConclusionAS1517499 could partially block the association between AD and asthma by specifically inhibiting the STAT6 signaling pathway.
Highlights
Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma
These skin lesions were significantly alleviated after treatment with AS1517499, and no significant changes were observed between the corn oil treatment (COTR) and AD groups (Fig. 2)
All of the results indicated that the repeated administration of DNCB increased the IL-33 level but inhibited IL-10 production, whereas the signal transducer and activation of transcription 6 (STAT6) inhibitor (AS1517499) significantly restored these levels
Summary
Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. Asthma is a complex chronic airway inflammatory disease characterized by airway inflammation and hyperresponsiveness. It is the result of genetic susceptibility and environmental factors and has obvious. Epidemiological studies have shown that the prevalence of allergic asthma and allergic rhinitis. Li et al Allergy, Asthma & Clinical Immunology (2022) 18:12 are increased in children if they suffer from AD before 5 years of age [6]. This disease progression from AD in infants to allergic asthma or asthma in children is termed the “allergic march.”. Researchers have made increasing efforts for clarifying the possible pathogenesis of the allergic march, from nutritional factors and environmental factors to genes [9, 10], but to no avail
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