Abstract
In this study, coenzyme Q10-loaded niosomes were prepared by thin film hydration method and the niosomes were further coated with PEG and chitosan (CS) at different mass ratio of PEG (or CS) to surfactant. The effects of different formulations on the physico-chemical properties of the carriers, including encapsulation efficiency (EE), drug loading capacity (LC), particle size and zeta potential were evaluated. These niosomes, including uncoated, PEG-coated and CS-coated niosomes, were subjected to stability examination, antioxidant activity analysis and sustained release studies. The results showed that PEG and CS modification effectively improved the hydroxyl radical scavenging activity of CoQ10. PEG coating could significantly increase the stability of loaded drug, including photo stability, heat stability and storage stability, and the best one was PEG/Surf 1:2. Furthermore, compared to CoQ10 solution, the PEG-coated niosomes exhibited an excellent sustained release effects, while the CS modification had the adverse effects. In conclusion, PEG-modified niosomes can be used as a new carrier for CoQ10.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
