Abstract
Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good physicochemical properties (entrapment efficiency = 57.1, particle size = 68.1 nm, polydispersity index = 0.246, and zeta potential = −3.16 mV). Compared with free curcumin, curcumin nanoliposomes exhibited good stability against alkaline pH and metal ions as well as good storage stability at 4 °C. Curcumin nanoliposomes also showed good sustained release properties. Compared with free curcumin, curcumin nanoliposomes presented an equal cellular antioxidant activity, which is mainly attributed to its lower cellular uptake as detected by fluorescence microscopy and flow cytometry. This study provide theoretical and practical guides for the further application of curcumin nanoliposomes.
Highlights
Curcumin, a yellow colored, low molecular weight polyphenol, is extracted from the rhizome of Curcuma longa [1]
The high solubility of curcumin in nanoliposomes (490.8 μg/mL) indicated that the water solubility of curcumin was significantly improved by nanoliposome encapsulation
Curcumin encapsulated in nanoliposomes became less stable at pH = 12.0, and 22.2% ± 4.1% of the curcumin remained in the nanoliposomes after 3 h incubation at this pH, while 37.1% ± 1.9% of curcumin was retained in free curcumin
Summary
A yellow colored, low molecular weight polyphenol, is extracted from the rhizome of Curcuma longa [1]. The utilization of encapsulations can protect the core material from adverse environmental conditions, and improve the half-life of compounds in both in vivo and in vitro systems, and enhance their bioavailability [15] Among these encapsulation methods, nanoliposomes are a potentially good delivery system due to their nanometer level size, biodegradability, low toxicity and capacity to encapsulate both hydrophobic and hydrophilic compounds [16]. There are no reports about whether curcumin could be stabilized by nanoliposomes when exposed to adverse alkaline solution and metal ion solution conditions. The focus of the present work was whether the stability of curcumin could be improved by nanoliposomes when exposed to adverse alkaline solutions and metal ion solutions. The cellular antioxidant activities and cellular uptake capacity of curcumin nanoliposomes were evaluated
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