The stability of the three transmembrane and the four transmembrane human vitamin K epoxide reductase models

Abstract

3 transmembrane and 4 transmembrane helices models are suggested for the human vitamin K epoxide reductase (VKOR). In this study, we investigate the stability of the human 3 transmembrane/4 transmembrane VKOR models employing a coarse-grained normal mode analysis and molecular dynamics simulation. Based on the analysis of the mobility of each transmembrane domain, we suggest that the 3 transmembrane human VKOR model is more stable than the 4 transmembrane human VKOR model.