Abstract
The inflammatory response plays out over time in a reproducible and organized manner after an initiating stimulus. Here we showed that the genes activated in cultured mouse fibroblasts in response to the cytokine tumor necrosis factor (TNF) can be divided roughly into three groups, each with different induction kinetics. Whereas differential transcription is important in determining the grouping of these genes, differential mRNA stability also exerted a strong influence—in some cases overriding that of transcriptional control elements—on the temporal order of gene expression. mRNA transcripts expressed early have abundant AU-rich elements in their 3′-untranslated regions whereas those expressed later contain fewer. Thus mRNA stability and transcriptional control, two intrinsic characteristics of genes, control the kinetics of proinflammatory cytokine-induced gene expression.
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