Abstract
DNA has been studied in electrolyte-containing glycol solutions. A sharp transition in secondary structure occurs within the temperature range 25°–40°, as judged from an increase in absorbancy at 260 mμ and a decrease of viscosity and transforming activity. Changes in viscosity and absorbancy of DNA in glycol at lower temperatures are reversible and not correlated with any change in transforming activity. Light-scattering experiments suggest an aggregation of DNA in glycol. The usefulness of glycol for preparative work on DNA is pointed out.
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