Abstract
Children with adverse reactions to cow's milk (CM) often are given infant formulas containing CM proteins (casein or whey proteins) modified by hydrolysis to reduce their allergenicity. Recently, a few reports of acute allergic reactions to these CM hydrolysates have appeared in the medical literature. Therefore, between January 1, 1989, and August 31, 1989, we studied 26 children with a current history of recurrent acute respiratory (asthma, 19/26) or cutaneous (26/26, urticaria) reactions to CM. They were prick skintested with CM, two whey hydrolysates (Good Start HA and Alfare), and two casein hydrolysates (Nutramigen and Alimentum). Serum-specific IgE (sIgE IU/ml) to CM was measured by the 3M Fast method. Unexpectedly, high frequencies of positive prick tests were found to the whey (69%) and to the casein (38%) hydrolysate products. On the basis of skin test positivity, patients could be separated into three groups: group A (n = 8, positive only to CM), group B (n = 8, positive to CM and whey hydrolys...
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