Abstract
A study was made of the effect of transfusion-induced polycythemia on the formation of intrasplenic clones in X-irradiated mice injected with bone marrow cells. Polycythemic animals showed a 3-fold decrease in the number of macroscopic clones obtained, as compared to non-polycythemic animals. Microscopic examination of the cell types of the spleen colonies revealed that the suppression effect of transfusion-induced polycythemia was cell specific: no erythroid clones were formed in the spleens of the polycythemic animals. Both cell replication and differentiation of the erythroid lines were completely inhibited. No such inhibition was observed among the granuloid colonies; in fact, an increased incidence of granuloid colonies was found in the polycythemic animals.
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