The spatio-temporal filtering hypothesis of the cerebellar cortex: evidence from VSD imaging

Abstract

Event Abstract Back to Event The spatio-temporal filtering hypothesis of the cerebellar cortex: evidence from VSD imaging Jonathan Mapelli1, 2*, Daniela Gandolfi1, 2 and Egidio D‘Angelo1, 2 1 University of Pavia and CNISM, Dept. of Physiology, Italy 2 IRCCS fondazione Mondino, Brain Connectivity Center, Italy The functional mechanisms of the cerebellar cortex are still object of debate and it is not fully clear how mossy fiber inputs are transformed in the granular layer and retransmitted to the molecular layer and Purkinje cells. Here the spatio-temporal properties of granular-to-molecular layer transmission in response to mossy fiber bursts of different frequencies have been investigated using voltage-sensitive dye imaging. The granular layer was optimally excited above ~50 Hz and the molecular layer responded above ~100 Hz with a steep gain curve. The high-pass filtering properties depended on GABA and NMDA receptors: NMDA receptors determined mossy fiber – granular layer frequency-dependence, while GABA receptors determined granular to molecular layer frequency-dependence. Moreover, GABA receptors reduced granular layer gain through a dynamic mechanism (-103%) rather than tonic inhibition (+17%). These results indicate that the mossy fiber pathway favors bursts-burst transmission, which is dynamically controlled by the local circuitry in a frequency dependent manner. Keywords: Cerebellum Conference: The Cerebellum: from neurons to higher control and cognition, Pavia, Italy, 8 Jul - 9 Jul, 2010. Presentation Type: Poster Presentation Topic: The Cerebellum: from neurons to higher control and cognition Citation: Mapelli J, Gandolfi D and D‘Angelo E (2010). The spatio-temporal filtering hypothesis of the cerebellar cortex: evidence from VSD imaging. Front. Neurosci. Conference Abstract: The Cerebellum: from neurons to higher control and cognition. doi: 10.3389/conf.fnins.2010.83.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Aug 2010; Published Online: 29 Aug 2010. * Correspondence: Mr. Jonathan Mapelli, University of Pavia and CNISM, Dept. of Physiology, Pavia, Italy, jonathan.mapelli@unipv.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jonathan Mapelli Daniela Gandolfi Egidio D‘Angelo Google Jonathan Mapelli Daniela Gandolfi Egidio D‘Angelo Google Scholar Jonathan Mapelli Daniela Gandolfi Egidio D‘Angelo PubMed Jonathan Mapelli Daniela Gandolfi Egidio D‘Angelo Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.