Abstract
Tinnitus Tinnitus reduces the quality of life for millions of sufferers worldwide. Using a guinea pig model of tinnitus induced by noise trauma, Marks et al. delivered precisely timed bimodal auditory-somatosensory stimulation to induce long-term depression (LTD) in the cochlear nucleus. Twenty minutes of treatment per day reduced physiological and behavioral evidence of tinnitus in the animals. The same bimodal protocol reduced tinnitus loudness in human subjects in a double-blind, sham-controlled, crossover clinical study. Unimodal stimulation did not reduce tinnitus in the animals or the humans. This approach thus holds promise for suppressing chronic tinnitus in patients. Sci. Transl. Med. 10 , eaal3175 (2018).
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