The somatosensory mismatch negativity as a window into body representations in infancy.

Abstract

How the body is represented in the developing brain is a topic of growing interest. The current study takes a novel approach to investigating neural body representations in infants by recording somatosensory mismatch negativity (sMMN) responses elicited by tactile stimulation of different body locations. Recent research in adults has suggested that sMMN amplitude may be influenced by the relative distance between representations of the stimulated body parts in somatosensory cortex. The current study uses a similar paradigm to explore whether the sMMN can be elicited in infants, and to test whether the infant sMMN response is sensitive to the somatotopic organization of somatosensory cortex. Participants were healthy infants (n = 31) aged 6 and 7 months. The protocol leveraged a discontinuity in cortical somatotopic organization, whereby the representations of the neck and the face are separated by representations of the arms, the hands and the shoulder. In a double-deviant oddball protocol, stimulation of the hand (100 trials, 10% probability) and neck (100 trials, 10% probability) was interspersed among repeated stimulation of the face (800 trials, 80% probability). Waveforms showed evidence of an infant sMMN response that was significantly larger for the face/neck contrast than for the face/hand contrast. These results suggest that, for certain combinations of body parts, early pre-attentive tactile discrimination in infants may be influenced by distance between the corresponding cortical representations. The results provide the first evidence that the sMMN can be elicited in infants, and pave the way for further applications of the sMMN in studying body representations in preverbal infants.