Abstract
THE INJECTION of insulin in a fasting animal causes a maximum decrease of the blood sugar within 2 hours, but the depression of the blood sugar is mani-fested for a longer period of time. This prolonged effect may be associated with the continued presence of insulin in the blood stream or to its persistent action in other tissues after it has disappeared from the circulation. Horsters (1) subscribes to the latter view. An answer to this problem may be obtained if the presence of insulin in the blood stream can be determined; obviously, when sufficiently large doses are injected intravenously into comparatively small laboratory animals, it may be shown that extracts made from the blood of such animals contain insulin.3 Each of 10 full-grown, unanesthetized rabbits received approximately 1000 U of insulin intravenously (50 mg. of insulin powder assaying about 20 U per mg.4 dissolved in 5 cc. of distilled water).
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