Abstract

Despite the availability of tuberculosis prevention and control services throughout Amazonas, high rates of morbidity and mortality from tuberculosis remain in the region. Knowledge of the social determinants of tuberculosis in Amazonas is important for the establishment of public policies and the planning of effective preventive and control measures for the disease. To analyze the relationship of the spatial distribution of the incidence of tuberculosis in municipalities and regions of Amazonas to the socioeconomic factors and indigenous tuberculosis component, from 2007 to 2013. An ecological study was conducted based on secondary data from the epidemiological surveillance of tuberculosis. A linear regression model was used to analyze the relationship of the annual incidence of tuberculosis to the socioeconomic factors, performance indicators of health services, and indigenous tuberculosis component. The distribution of the incidence of tuberculosis in the municipalities of Amazonas was positively associated with the Gini index and the population attributable fraction of tuberculosis in the indigenous peoples, but negatively associated with the proportion of the poor and the unemployment rate. The spatial distribution of tuberculosis in the different regions of Amazonas was heterogeneous and closely related with the socioeconomic factors and indigenous component of tuberculosis.

Highlights

  • Tuberculosis (TB) is considered a serious public health problem in Brazil, with about 70,000 new cases and 5,000 deaths registered annually [1]

  • The highest incidence rate was found in the region where the state capital is located, in Entorno de Manaus and Rio Negro (East), with 74 cases per 100,000 inhabitants (Table 1)

  • The spatial distribution of TB in the state of Amazonas that was characterized in this study reveals a pattern that can be explained by two different conditions: (i) higher incidence in densely populated areas such as in the capital, Manaus, and (ii) in populations with a large indigenous contingent as in the regions of Entorno de Manaus and Rio Negro (West), and Rio Juruá

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Summary

Introduction

Tuberculosis (TB) is considered a serious public health problem in Brazil, with about 70,000 new cases and 5,000 deaths registered annually [1]. Brazil is one of 22 countries that account for 80% of the TB cases worldwide and, in 2013, ranked 16th in the list of countries with the highest number of new cases [2]. The Brazilian state of Amazonas had the highest TB incidence rate in 2013, with 70.6 cases per 100,000 inhabitants. The average incidence rate in the country was 35.4 cases per 100,000 residents. Amazonas had the highest mortality rate in the PLOS ONE | DOI:10.1371/journal.pone.0158574. Amazonas had the highest mortality rate in the PLOS ONE | DOI:10.1371/journal.pone.0158574 June 30, 2016

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