The so-calle "Cloverleaf Skull Syndrome". A report of three cases with a discussion of its relationships with thanatophoric dwarfism and the craniostenoses.

Abstract

Three cases of cloverleaf skull are reported, one in a newborn with generalized bone changes suggesting thanatophoric dwarfism, one in an infant with acrocephalosyndactyly, and the other in an infant with several features of Crouzon's disease. The relationships between cloverleaf skull, on one side, and thanatophoric dwarfism and the severe craniostenoses, on the other, are discussed. The cloverleaf deformity should be considered a purely morphologic feature in common to several diseases, and should no longer be considered a separate “syndrome”.