Abstract
Simple SummaryObstructive sleep apnea syndrome (OSA) and non-alcoholic fatty liver disease (NAFLD) are very common and share underlying metabolic risk factors. It remains unclear how exactly the two diseases are related. In this study, patients with obstructive sleep apnea were evaluated for the presence of NAFLD with the aim of finding parameters in polysomnography that may indicate NAFLD. The snoring index turned out to be the most valuable and a very reliable screening tool for the presence of NAFLD—independent of other metabolic risk factors.Background: The aim of this observational cohort study was to explore the severity of liver disease in patients with suspected obstructive sleep apnea in Germany. Methods: Patients undergoing polysomnography or home sleep apnea testing (HSAT) as an evaluation for the presence of OSA were screened using vibration-controlled transient elastography (VCTE) and continuous attenuation parameter (CAP) with a Fibroscan ® Mini 430. Clinical and laboratory data were collected following the overnight exam. Results: In total, 78 patients (28 female (35.9%), mean age 54.2 years) with OSA defined by an apnea-hypopnea-index >5 events/hour were included between OCT 2020 and APR 2021. Patients exhibited a high metabolic risk profile with 17% known diabetes mellitus type 2 (T2D), 62% arterial hypertension, 14% hyperlipidemia and 36% BMI > 30 kg/m2. The prevalence of steatosis defined by a CAP > 280 dB/m was 54%. The prevalence of at least significant fibrosis was 16% (E > 9.0 kPa). Interestingly, patients with a snoring index above the median of 278/h showed significantly higher CAP-values (p = 0.0002). In addition, the proportion of oxygen saturations below 90% (t90) correlated with CAP-values (p = 0.02), as well as metabolic risk factors including increased waist circumference (p = 0.005) and body mass index (BMI) (p = 0.035). On the other hand, the apnea-hypopnea-index (AHI) as a marker of OSA severity did not correlate with VCTE, CAP or laboratory parameters. Conclusion: Patients with moderate to severe OSA have a high prevalence of hepatic steatosis. The snoring index is an easy-to-use clinical tool to identify patients at risk for relevant liver disease within the larger group of patients with OSA.
Highlights
It is estimated that 23.4% of women and 49.7% of men suffer from moderate to severe obstructive sleep apnea (OSA) in central Europe [1]
Intermittent hypoxia has shown to cause insulin resistance, and dysfunction of key steps in hepatic lipid metabolism, atherosclerosis, hepatic steatosis and fibrosis, each of which is pertinent to the development and/or progression of non-alcoholic fatty liver disease (NAFLD) [9]
In this observational cohort study patients with confirmed OSA who presented at the sleep outpatient department between OCT 2020 and APR 2021 were included in the study and screened for NAFLD via liver elastography
Summary
It is estimated that 23.4% of women and 49.7% of men suffer from moderate to severe obstructive sleep apnea (OSA) in central Europe [1]. Like OSA, the non-alcoholic fatty liver (NAFL) shows a high prevalence in the general population. OSA is characterized by cyclic intermittent nocturnal hypoxia as a consequence of recurrent apneas and hypopneas. Intermittent hypoxia has shown to cause insulin resistance, and dysfunction of key steps in hepatic lipid metabolism, atherosclerosis, hepatic steatosis and fibrosis, each of which is pertinent to the development and/or progression of NAFLD [9]. The aim of this observational cohort study was to explore the severity of liver disease in patients with suspected obstructive sleep apnea in Germany.
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