Abstract
The Smc5/6 complex and the difficulties cutting the ties of twin sisters
Highlights
The link between Smc5/6 and DNA repair was known for some time, details of Smc5/6 functions are just beginning to be uncovered
Inactivation of Smc5/6 results in DNA damage checkpoint activation only in the following cell cycle [6,8], which is consistent with damages occurring during mitosis
Part of the answers to these nagging questions could come from the proposition that failure to disjoin rDNA in smc5/6 mutants is caused by cell division in presence of normal ongoing replication forks at the rDNA locus [10]
Summary
The link between Smc5/6 and DNA repair was known for some time, details of Smc5/6 functions are just beginning to be uncovered. It was proposed that Smc5/6 resolves particular HR intermediates generated in an attempt to repair stalled or defective replication forks [5,6,9]. Failure to resolve these chromatid-linking structures would lead to chromosome breakage at cell division. Inactivation of Smc5/6 results in DNA damage checkpoint activation only in the following cell cycle [6,8], which is consistent with damages occurring during mitosis.
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