The SLP estimation of the nanoparticle systems using size-dependent magnetic properties for the magnetic hyperthermia therapy

Abstract

Magnetic Nanoparticle hyperthermia (MNH) is one of the hyperthermia therapy in which temperature gain is achieved through magnetic nanoparticles in the tumor tissue/targeted region. The key parameters for efficient heating in MNH are magnetic nanoparticle (MNPs) properties, its size & materials, and magnetic field parameters (amplitude and frequency). Thus, the present study investigates the effects of these parameters on heat generation during MNH. In this study, a comparison of heat generation by three nanoparticle systems (CoFe2O4, Fe3O4, and MnFe2O4) and its dependency on size & magnetic field parameters is theoretically investigated. The quantification of specific loss power (SLP) of nanoparticle systems depending on its size-dependent saturation magnetization (MS) and the anisotropy constant (Keff). of nanoparticles has been done in this work. Correlations for MS and Keff based on the previously reported experimental data have been established for considered MNP systems. The comparisons show that SLP estimation using MNP size-dependent saturation magnetization (MS) (Fig. 4) are closer to the experimentally reported values of SLP for all considered MNP systems (CoFe2O4, Fe3O4, MnFe2O4) in comparison to SLP estimated by fixed values of saturation magnetization (MS) and anisotropy constant (Keff). Results show that dissipated power reaches a peak at a certain particle size (DO). However, the (DO) varies with the magnetic field frequency and amplitude. It decreases as the frequency increases at a particular field amplitude. In addition, the SLP increment ceases after a certain frequency (fO) that is around 500 kHz for considered MNP systems. On the other hand, the SLP continuously increases with an increase in field amplitude. Thus this work incorporates the empirical correlations as well as experimental data to predict the SLP for three magnetic nanoparticle systems generally utilized in the MNH.