The slow release behavior of soy protein isolate/κ-carrageenan composite hydrogel: Effect of konjac glucomannan

Abstract

Composite hydrogels are known for their potential applications in drug delivery fields. Pure κ-carrageenan (KC) hydrogels have a drug burst release behavior, which greatly limit their applications. In this study, konjac glucomannan (KGM) was used to further improve the properties of soy protein isolate (SPI)/KC composite hydrogels. The results showed that the viscoelasticity of the composite hydrogels increased at KC/KGM ratio 9:1 due to the increase of hydrogen bond interaction. Excessive addition of KGM in composite hydrogels led to the increase in frequency dependence and gel network cavity as well as the decrease in gel cohesiveness. In vitro study on glucose release behavior of composite hydrogels showed that the glucose slow release behavior was enhanced by a small amount of KGM incorporation and had highly positive correlation with the gel viscoelasticity. These results suggested that KGM had the potential to enhance the properties and drug release characteristics of composite hydrogels.