The sleep EEG topography in children and adolescents shows sex differences in language areas

Abstract

The topographic distribution of slow wave activity (SWA, EEG power between 0.75 and 4.5Hz) during non-rapid eye movement (NREM) sleep was proposed to mirror cortical maturation with a typical age-related pattern. Here, we examined whether sex differences occur in SWA topography of children and adolescents (22 age-matched subjects, 11 boys, mean age 13.4years, range: 8.7–19.4, and 11 girls, mean age 13.4years, range: 9.1–19.0years). In females, SWA during the first 60min of NREM sleep was higher over bilateral cortical areas that are related to language functions, while in males SWA was increased over the right prefrontal cortex, a region also involved in spatial abilities. We conclude that cortical areas governing functions in which one sex outperforms the other exhibit increased sleep SWA and, thus, may indicate maturation of sex-specific brain function and higher cortical plasticity during development.