The size of the ciliary body in human enucleated chronic angle‐closure glaucoma

Abstract

Aims/Purpose:: The size of the body of the ciliary stroma in relation to the morphology of the angle of the anterior chamber in human enucleated eyes.Methods: A histomorphometric analysis of enucleated human eyes using a light microscope.Results: 107 enucleated human eyes (mean axial length 25.1 ± 2.8 mm; range 21.0–36.0 mm) were included for analysis using light microscope. 68 of those eyes had an open anterior chamber angle and 39 had an endothelialized and closed angle. The body of the ciliary stroma measured was broadest with 541 ± 210 μm vs 59 ± 179 μm (p < 0.001) and narrowest with 214 ± 107 μm vs 17 ± 55 μm (p < 0.001) and the highest ciliary muscle height was 593 ± 557 μm vs 293 ± 111 μm (p < 0.001). In the angle‐closure group these parameters were significantly smaller, than in the open‐angle group. The width of the broadest section of the stroma of the ciliary body increased with the presence of an open‐angle anterior chamber (beta:0.82; B:517; 95%CI:435599; p < 0.001) and a longer axial length (beta:0.17; B:18.2; 95%CI:4.2,32.2; p = 0.01). The width of the narrowest section of the stroma of the ciliary body correlated with an open anterior chamber angle (beta:0.65; B:177; 95%CI:140213; p < 0.001) and an increase in the height of the ciliary body muscle (beta:0.23; B:0.06; 95%CI:0.03,0.10; p = 0.001). The height of the ciliary body muscle increased with increasing maximal height of the stroma (beta:0.43; B:1.54; 95%CI:0.92,2.17; p < 0.001).Conclusions: The size of the stroma of the ciliary body in eyes with an angle of the anterior chamber closed by endothelial cells is smaller than in open‐angle eyes. Due to the tightening of the anterior angle the access of aqueous humour to the trabecular meshwork and to the ciliary body stroma may cause a reduction of the uveoscleral or uveovortex outflow.