The situation and feature of the intensive insulin therapy in a group of hyperglycemic patients during pregnancy

Abstract

Relevant clinical data of 141 cases diagnosed pregestational diabetes mellitus(PGDM), diabetes mellitus in pregnancy(DIP), gestational diabetes mellitus(GDM), and type 2 diabetes mellitus(T2DM)were collected. The blood glucose control rate, insulin dose, and episode of hypoglycemia in the insulin intensive therapy were retrospectively analyzed. The results showed that there was no significant difference in the control rate among the four groups(P=0.906). The insulin dose/weight in GDM was significantly lower than those in PGDM, DIP, and T2DM groups [0.65(0.47-1.00), 0.67(0.38-1.05), 0.65(0.52-0.82)vs 0.45(0.29-0.61)U·kg-1·d-1, P<0.05 or P<0.01]. There was no significant difference in episode or incidence rate of hypoglycemia among the overall four groups(P=0.339). However in the patients with blood glucose reaching the control standard, the rate of hypoglycemia in T2DM was significantly higher than those in PGDM, DIP, and GDM(P<0.05 or P<0.01). (Chin J Endocrinol Metab, 2018, 34: 304-307) Key words: Pregestational diabetes mellitus; Gestational diabetes mellitus; Insulin intensive therapy; Hypoglycemia