Abstract
The site of action, on which the efficaciousness of iodine in the treatment and prevention of certain types of goiter depends, does not seem to have been determined. The types of goiter particularly indicated arc exophthalmic and colloid, yet it is equally as valuable in most instances of adenomata with hyperthyroidism. Failures occur in all types on some occasions. The accepted opinion seems to be that a colloid goiter develops because the amount of iodine supplied in the diet is inadequate. The gland enlarges to compensate for this deficiency by depositing colloid in the lumen of the acini of which the gland is composed. The cells regress in their activity, so that the general metabolism readings vary, if sufficient inhibition be present, toward the low normal figures. Some investigators state that the deficiency of iodine is relative to other factors. In exophthalmic goiter there is conceded by all investigators to be an increase in the size and number of thyroid cells, as well as an increase in the number of acini. The general metabolism readings, during periods of activity, are above the normal figures.
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