Abstract
The specificity of antibodies that detect the antigens I, i, I^T, IH (10), IA, IB, iH (iO), and IP(1) [23, 10, 21, 11, 12, 3, 16, 17, 2, 5, 18, 22, 4, 20, 6, 7] can be established with little difficulty. There remain, however, many cold agglutinins that do not have specificity directed against any one of these antigens; this paper describes studies on 22 such sera, 3 of which react equally with I and i cells (regardless of ABO group) and 19 of which have anti-I specificity but react with significant strength with i cells as compared to a ‘standard’ anti-I. Absorption and elution experiments with selected erythrocytes show that all 22 sera contain separable anti-I and anti-i.
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