Abstract
The present study investigated the design optimization of aerosol micro atomizer for liquid pulmonary device. Pulmonary delivery device with a micro atomizer at the tip is commonly used to penetrate into a small animal’s trachea, and directly quantitatively spray the infected dosing aerosol samples to animal’s lung. In order for no damage to animal’s trachea, a long capillary with a diameter of 0.5-0.6 mm is used for flow diversion. Therefore, the swirl atomizer size of the head is required to be adequately tiny with uniformity and penetration of aerosol spray. Due to structural limitation without adequate rotational space, it is highly challenging to provide the fine atomization with high quality. Therefore, based on the simulation analysis in Simspray software, the optimization design of the micro atomizer is conducted, aiming to improve the atomization quality with a certain spray angle. Parametric study on swirl atomizer structure, including swirl pitch, nozzle diameter and size of swirl channel, realized an excellent combination of parameters to meet requirement of fine spray. The experiment testifies that the 3-5μm aerodynamic diameter of droplets in spray is available.
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