Abstract
Introduction: Urotensin - II (U-II) is a small peptide of 11 to 14-amino acids containing a ring structure of 6-amino acids which is highly conserved in all organisms. UT-II and its receptors have been confined in human cerebrum, spinal line, heart (ventricular myocardium), vascular (endothelial and smooth muscle) tissues, kidney, thyroid and skeletal muscles. The discovery of U-II as an endogenous ligand of GPR14 has rekindled the interest in its physiological as well as pathophysiological role in humans.
 Objective: Objective of the manuscript is to develop better understanding of its binding to the receptor, its secondary messenger system and mechanism of termination of action, we will be better equipped to tame its properties.
 Conclusion: This review explained about chemical structure of Urotensin-II, U-II and UT receptor, UT antagonists and a correlation with cardiovascular diseases like arthrosclerosis, congestive cardiovascular breakdown and diabetes.
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