Abstract
1. 1. The nucleus raphe dorsalis (DR) and surrounding brain areas were electrolytically lesioned in fully awake, unrestrained rats. 2. 2. Raphe lesions caused a delay in the onset of response to cold stress, resulting in a larger drop of hypothalamic temperature, whereas in steady state both oxygen consumption and hypothalamic temperature were unchanged compared to intact animals. 3. 3. Lesions which damaged the periventricular grey only had no effect. 4. 4. The response to heat stress was unchanged after all lesions. 5. 5. Concerning thermoafferent pathways, mainly warm responsive neurons have been described in the raphe nuclei. A damage of the thermoafferent systems should therefore cause a disturbance of heat defence. This is not the case. We conclude that the DR has an excitatory influence on thermoregulatory effector mechanisms.
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