Abstract
There is good evidence that there are significantly low sex ratios (proportions male) in the offspring of patients with some immune diseases e.g. systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There is also strong evidence that there are significantly low sex ratios in the sibs of patients with SLE and RA and it has been suggested that the low SLE sib sex ratio may be explained by male fetal loss. However, no explanations for these low sex ratios has been established. Bearing in mind the posited hormonal involvement in immune processes, this paper suggesst an additional potential solution. It is that both the pathology and the sex ratio share a hormonal cause - testosterone. The argument depends on the hormonal hypothesis of sex ratio. This paper will describe the hypothesis and describe its relevance to SLE and RA.
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