The significance of standard deviation of blood glucose in the continuous glucose monitoring of the subjects with different stages of glucose tolerance

Abstract

Objective To investigate the significance of standard deviation of blood glucose in the continuous glucose monitoring of the subjects across a range of glucose tolerance from normal to overt type 2 diabetes.Methods Totally 220 subjects were recruited in the study,including 47 with normal glucose regulation (NGR),52 with impaired glucose tolerance (IGT,20 with isolated impaired glucose tolerance,and 32 with IGT and impaired fasting glucose),61 with diabetes diagnosed by isolated 2 h plasma glucose (DM2h),and 60 newly diagnosed diabetes by both fasting and 2 h plasma glucose (DM).All subjects were monitored by using the continuous glucose monitoring system for consecutive 72 hours.The multiple parameters of glycemic variability included the standard deviation of blood glucose (SD),continuous overlapping net glycemic action calculated every 1 h (CONGA1),mean of daily differences(MODD),and mean amplitude of glycemic excursions (MAGE).Results Glycemic variability parameters,including SD,CONGA1,MODD,and MAGE,all increased from NGR to IGT,DM2h,DM group (P＜0.05).However,MAGE/SD,MODD/SD,and CONGA1/SD were comparable in the NGR,IGT,DM2h,and DM groups(P=0.988,0.320,and 0.350,respectively).The ratios of MAGE,MODD,and CONGA1 to SD in the entire data set were 2.24 ± 0.43,0.94 ± 0.17,and 0.89 ± 0.24,respectively.Conclusions There were direct linear proportionalities between MAGE,MODD,CONGA1,and SD for each glucose tolerance group or the entire data set.MAGE,MODD,and CONGA1 can be calculated according to SD. Key words: Glycemic variability ; Continuous glucose monitoring ; Standard deviation of blood glucose ; Diabetes mellitus, type 2