Abstract
Objective. To investigate the serum level of CA-125 and its corresponding clinical significance in Chinese patients with primary BCS. Methods. Serum CA-125 was measured in 243 patients with primary BCS receiving interventional treatment in the participating hospitals and in 120 healthy volunteers. The correlation between serum CA-125 levels and ascites volume, liver function, and prognosis was analyzed. Results. Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001). Higher levels of CA-125 were found in BCS patients with abnormal hepatic function and low serum albumin levels and in patients with high volume of ascites compared to patients without these abnormalities. Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores. The follow-up study indicated that the survival rate and asymptomatic survival rate after interventional treatment were lower in BCS patients with serum CA-125 > 175 U/mL (P < 0.05). Conclusion. Serum CA-125 was significantly higher in patients with primary BCS and had a positive correlation with the volume of ascites, severity of liver damage, and poor prognosis. Thus the serum CA-125 levels may be used to estimate the severity and prognosis of BCS in Chinese patients.
Highlights
Budd-Chiari syndrome (BCS) is a rare and clinically challenging disorder defined as the obstruction of hepatic venous outflow anywhere from the small hepatic veins to the suprahepatic inferior vena cava [1,2,3]
The clinical features and risk factors of the BCS patients are detailed in Tables 1 and 2
BCS patients (N = 243 including 147 males and 96 females) with an average age of 46.3 ± 11.4 years and 120 healthy volunteers (67 males and 53 females) with an average age of 45.1 ± 14.2 years were recruited into the study
Summary
Budd-Chiari syndrome (BCS) is a rare and clinically challenging disorder defined as the obstruction of hepatic venous outflow anywhere from the small hepatic veins to the suprahepatic inferior vena cava [1,2,3]. BCS is classified as primary or secondary depending on the cause of the obstruction. BCS remains a rare disease with an incidence rate of 1-2 cases per million per year, a study in Japan estimated a prevalence of 2.4/million with 20 new cases being diagnosed each year. The clinical presentation of BCS is dependent on the extent of hepatic vein occlusion, based on which the syndrome can be classified as fulminant, acute, subacute, or chronic. When the inferior vena cava is occluded, dilated venous collaterals are present in the flanks, along with pedal edema, varicose veins, and pigmentation of lower extremities [1, 6, 7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
