Abstract
BackgroundLung adenocarcinoma (AD) is a common variant of non-small cell lung cancer (NSCLC). Programmed cell death protein 1/programmed cell death ligand 1 (PD1/PD-L1) are promising immunotherapy targets and its expression may be an important biomarker of predicting clinical response. In this study, we evaluated PD-L1 expression in conjunction with clinicopathological characteristics and outcomes in resected lung adenocarcinoma.ResultsThis study included 133 cases of lung adenocarcinoma. PD-L1 expression rate in lung adenocarcinoma was 16.5% at the mRNA level and 13.5% at the protein level, and the kappa coefficient of the two examination methods was 0.824 (P = 0.219, highly correlated). PD-L1 was highly expressed in male patients and smokers with lung adenocarcinoma (P = 0.019 and 0.002, respectively), while no associations were identified between PD-L1 expression and age, tumor size, clinical stage, positive pleural invasion, lymph node metastasis, or therapy methods. Overexpression of PD-L1 was a significant indicator of shorter recurrence free survival time and overall survival (P = 0.000 and 0.000, respectively). Multivariate analysis revealed that PD-L1 expression was an independent risk factor for poor recurrence free survival and overall survival (P = 0.009 and 0.016, respectively).Materials and MethodsExpression of PD-L1 was examined with immunohistochemistry, using the VENTANA PD-L1 (SP263) rabbit monoclonal antibody. mRNA levels of PD-L1 were evaluated using in situ hybridization.ConclusionsPD-L1 overexpression is more frequently observed in male patients and smokers in lung adenocarcinoma. PD-L1 expression is an indicator of worse prognosis in surgically resected lung adenocarcinoma patients.
Highlights
Lung adenocarcinoma is a common variant of nonsmall cell lung cancer (NSCLC)
Programmed cell death ligand 1 (PD-L1) was highly expressed in male patients and smokers with lung adenocarcinoma (P = 0.019 and 0.002, respectively), while no associations were identified between PD-L1 expression and age, tumor size, clinical stage, positive pleural invasion, lymph node metastasis, or therapy methods
Multivariate analysis revealed that PDL1 expression was an independent risk factor for poor recurrence free survival and overall survival (P = 0.009 and 0.016, respectively)
Summary
Lung adenocarcinoma is a common variant of nonsmall cell lung cancer (NSCLC). In recent years, there have been dramatic advances in the treatment of lung adenocarcinoma because of the development of therapies targeting driver oncogene alterations, for example, drugs targeting the epidermal growth factor receptor (EGFR) mutation or the anaplastic lymphoma kinase (ALK)fusion [1, 2]. Lung adenocarcinoma is a common variant of nonsmall cell lung cancer (NSCLC). Immune check-point inhibition therapy has shown promising results in several kinds of malignant tumors, including NSCLC [6]. Immune checkpoint inhibitor therapy can block the ligand- receptor interaction and activate a T cell immune response to attack the tumor cells. Programmed cell death protein 1/ programmed cell death ligand 1 (PD-1/PD-L1) is a major immune checkpoint signaling pathway. The binding of PD-L1 to PD-1 can block the immune response of T cells to the tumor cells. There are several ongoing clinical trials targeting NSCLC with PD-L1 protein. Lung adenocarcinoma (AD) is a common variant of non-small cell lung cancer (NSCLC). Programmed cell death protein 1/programmed cell death ligand 1 (PD1/PD-L1) are promising immunotherapy targets and its expression may be an important biomarker of predicting clinical response. We evaluated PDL1 expression in conjunction with clinicopathological characteristics and outcomes in resected lung adenocarcinoma
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