The significance of p40 expression in sclerosing hemangioma of lung.

Jian Wu,Chang Zhang,Haiguo Qiao

doi:10.1038/srep06102

Abstract

To explore the histogenesis of cuboidal and polygonal tumor cells in the sclerosing hemangioma of lung (SHL), eighteen cases of SHL were retrospectively studied. SPB, p40, TTF-1,EMA,CKpan, vimentin,SMA, CgA,Syn and CD34 were immunohistochemically labeled by the EnVisionmethod. It was found that the four main types of structure in SHL were solid,papillary, hemorrhagic and sclerotic patterns. The tumor cells were composed mainly of two types of cells: cuboidal tumor cells and polygonal tumor cells. The immunohistochemistry showed that p40 was expressed only in cuboidal tumor cells. TTF-1 and EMA were expressed in both polygonal cells and cuboidal cells. SPB was also expressed in cuboidal tumor cells; vimentin was expressed in all polygonal tumor cells and some cuboidal cells. The findings suggest that the p40-positive cuboidal tumor cells may be pluripotent original respiratory epithelial cells, with multi-directional differentiation capacity.

Highlights

To explore the histogenesis of cuboidal and polygonal tumor cells in the sclerosing hemangioma of lung (SHL), eighteen cases of SHL were retrospectively studied
The endothelial origin was not supported by subsequent studies; only tumor vascular endothelial cells were positively labeled, while endothelial cell markers of both polygonal tumor cells and cuboid tumor cells were unlabeled5.endothelial cells might be the squeezed alveolar epithelial cells. 2.Mesothelial cell origin, which was described by Katzensteinal, et al.[7]
Expression of CgA and Syn in polygonal tumor cells was observed in only one case, and no electron dense granules of typical neuroendocrine particle morphology were observed under the electronmicroscope

Summary

Introduction

To explore the histogenesis of cuboidal and polygonal tumor cells in the sclerosing hemangioma of lung (SHL), eighteen cases of SHL were retrospectively studied. It was found that the four main types of structure in SHL were solid,papillary, hemorrhagic and sclerotic patterns. The immunohistochemistry showed that p40 was expressed only in cuboidal tumor cells. TTF-1 and EMA were expressed in both polygonal cells and cuboidal cells. SHL is a well-circumscribed parenchymal tumor, which consists of two types of tumor cells: cuboidal tumor cells and polygonal tumor cells. In SHL, there are mainly four types of structure: solid, papillary, hemorrhagic and sclerotic patterns. The cuboidal cells were considered to be entrapped alveolar pneumocytes and bronchiolar epithelium, and polygonal cells were considered to be tumor cells. The objective of this study is to explore the histogenesis of SHL by analyzing the clinical pathological data and p40 immunohistochemical results of 18 cases of SHL

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Conclusion