Abstract
Background. Argyrophilic nucleolar organizer region (AgNOR) has been demonstrated in recent studies of human brain tumors, including meningiomas. The authors used this technique in meningiomas to analyze whether the mean numbers of AgNOR per nucleus (AgNOR score) are related to the recurrence rate or the proliferative potential of meningiomas. Methods. AgNOR staining technique was applied to paraffin-embedded sections of 60 meningiomas. Twenty of these specimens also were investigated immunohisto-chemically with monoclonal antibody (MoAb) against DNA polymerase α (Pol.α) and with MoAb Ki-67 to compare the AgNOR score with the proliferative potential. Results. There was a statistically significant difference between the AgNOR score in nonrecurrent meningiomas (2.48 ± 0.73) and recurrent histologically benign meningiomas after gross total resection (3.20 ± 0.96) (P < 0.02). The recurrence rate of tumors after gross total resection with an AgNOR score of 3.0 or more was significantly higher than that with an AgNOR score of less than 3.0. The AgNOR score did not always correlate with Pol.α or Ki-67 score; the AgNOR score of malignant meningioma that had high proliferative score was not always high. Conclusions. This study indicates that AgNOR staining appears to be a simple and useful method for estimating the probability of histologically benign meningioma recurrence even after gross total resection.
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