The significance of local cerebral hemodynamics in patients with acute brain injury

Abstract

Objective To investigate the relevance between the seriousness of acute brain injury and regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) or mean transition time (MTT); provide a possible method for the early diagnose and prognostic evaluation. Methods This study included 67 patients of acute brain injury and they were divided into mild, moderate and severe groups based on their glasgow coma scale (GCS) scores. They were examined to detect rCBF, rCBV and MTT by computed tomography perfusion (CTP) imaging after admitted to hospital. The prognoses of them after 6 months of follow-up were also recorded. The relations between the prognosis and rCBF, rCBV or MTT were analyzed. Results rCBV and rCBF of severe group were significantly lower than the mild group (P<0.05), and MTT of severe group was significantly higher than that of the mild group (P<0.05). The rCBV and the glasgow outcome scale (GOS) scores were significantly positively correlated(P<0.01), and MTT was significantly negatively correlated with the GOS score(P<0.01). Whereas there was no correlation between rCBF and the GOS score. Conclusion rCBF, rCBV and MTT were significantly correlated with the severity as well as the prognosis of patients with acute brain injury and they might be used as potential indicators of the severity and prognosis. Key words: Craniocerebral trauma; Regional cerebral blood flow; Regional cerebral blood volume; Mean transit time