Abstract
Summary The determination of peptide hydroxyproline in the serum and urine after gelatin ingestion has been found to be of value in the in vivo assessment of proteolytic activity. Normal individuals demonstrated rapid absorption and excretion of peptide hydroxyproline. In contrast, delayed serum and urinary peptide hydroxyproline peak values were found in two patients with severe pancreatic insufficiency. In addition, depressed serum glycine, proline, and alanine levels were noted in these patients after gelatin ingestion. Therapy with Cotazym and with Cotazym plus sodium bicarbonate was dramatically effective, restoring the peptide hydroxyproline levels to normal values. A patient with untreated adult celiac disease had a low absolute increase in urinary hydroxyproline after gelatin ingestion, as well as an elevated and delayed peptide hydroxyproline level in the serum. Patients with treated celiac disease demonstrated rapid absorption and excretion of hydroxyproline peptides.
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