Abstract
Abstract The anti-acetylcholine potencies of the dimethylaminoethyl and N/-methyl piperidin-4-yl esters of R and S 2-cyclohexyl-2-hydroxy-2-phenylacetic acid and their quaternary derivatives have been measured by in vitro and in vivo procedures. The R-enantiomer of dimethylaminoethyl-2-cyclohexyl-2-hydroxy-2-phenylacetate was approximately 100 times more active than the corresponding S-enantiomer both in vivo and in vitro. In contrast, the differences in potencies of the enantiomers of the other compounds were smaller in vivo than in vitro and moreover, the in vivo differences in potency decreased as the potency of the racemates increased. The relevance of these results to general studies of enantiomeric differences is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
