Abstract

Breast cancer ranks among the most prevalent malignancies in women to cause bone metastasis,which the main mechanism is osteolytic bone metastasis.There is a balance between the formation of new bone by osteoblasts and the resortion of old bone by osteoclasts in normal bone metabolism.Cancer cells within bone marrow interfere this balance and cause the change of the corresponding bone metabolism indicators,and this change can be detected through blood or urine.Bone-specific markers researched recently can be summarized as bone resorption markers and bone formation markers,the former include tartrate-resistant acid phosphatase 5b(Tracp5b),carboxy-terminal telopeptide of type Ⅰ collagen (ICTP),N-terminal and C-terminal cross-linked telopeptide of type Ⅰ collagen (NTx/CTx),pyridinoline(PYD) and droxypyridinoline (D-PYD),while the latter consist of bone isoenzyme of alkaline phosphatase(BAP),N-terminal propeptide of type Ⅰ procollagen (PINP),carboxy-terminal propeptide of type Ⅰ procollagen (PICP),bone sialoprotein (BSP),osteocalcin (OC),et al.These laboratory tests can provide more evidences for an early diagnosis of breast cancer with bone metastases. Key words: Breast cancer; Bone metastasis; Bone metabolic markers

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